Prognostic Significance of Creatinine Clearance in Patients With Heart Failure and Normal Serum Creatinine

نویسندگان

  • Elisabet Zamora
  • Josep Lupón
  • Agustín Urrutia
  • Beatriz González
  • Dolores Mas
  • Crisanto Díez
  • Salvador Altimir
  • Vicente Valle
چکیده

La insuficiencia renal es un importante factor pronóstico en pacientes con insuficiencia cardiaca. Para valorar la función renal se suelen utilizar las cifras de creatinina sérica. Sin embargo, cifras normales pueden ocultar una insuficiencia renal establecida. Hemos evaluado el significado pronóstico del aclaramiento de creatinina estimado (Cockcroft) en 235 pacientes con insuficiencia cardiaca y cifras de creatinina normales. Los pacientes con insuficiencia renal establecida (aclaramiento < 60 ml/min) tuvieron una mortalidad a 2 años muy superior a la de aquellos sin ella (el 35,1 y el 10,1%; p < 0,001). Incluso al analizar exclusivamente a los pacientes sin insuficiencia renal establecida, el aclaramiento de creatinina demostró tener significación pronóstica (≥ 90 ml/min, mortalidad del 3,2%; 89-60 ml/min, mortalidad del 13,9%; p = 0,02). En el análisis de regresión de Cox en el que se incluyeron además edad, sexo, etiología de la insuficiencia cardiaca, clase funcional, fracción de eyección de ventrículo izquierdo, diabetes e hipertensión, el aclaramiento de creatinina permaneció como predictor independiente de mortalidad.

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تاریخ انتشار 2017